The Little Foundation is a London-based charity operating internationally.

The charity was named in honour of William Little, the English surgeon who described what became known as "Little's disease", a spastic paralysis of both lower limbs which later became known as infantile cerebral palsy. Established in 1990 by the founder of Scope, the late Ian Dawson-Shepherd, the charity focuses on funding research into the causes of cerebral palsy and also has broader objectives seeking to fund research into not only the causes and prevention of cerebral palsy but also allied disorders which include autism, dyslexia, epilepsy, deafness and blindness, learning difficulties, and other forms of neurodevelopmental disorder.